Recommended control tissue：Lymphoid tissues containing follicular centers.
Staining pattern: neulcei
bcl-6 is a a transcriptional repressor which is necessary for germinal center formation.
This antibody is react with normal germinal center B-cells. In malignant lymphomas, it is positive for those with germinal center differenrtiation, such as follicular lymphoma and Burkitt lymphoma etc.
Fig: bcl-6 positive diffuse large B-cell lymphoma