Scoring system of acute cellular rejection in liver transplantation
2015年9月21日
| score | ||
| Portal Inflammation (P) |
Mostly lymphocytic inflammation involving, but not noticeably expanding, a minority of the triads | 1 |
| Expansion of most or all of the triads, by a mixed infiltrate containing lymphocytes with occasional blasts, neutrophils and eosinophils | 2 | |
| Marked expansion of most or all of the triads by a mixed infiltrate containing numerous blasts and eosinophils with inflammatory spillover into the periportal parenchyma | 3 | |
| Bile Duct Inflammation Damage(B) |
A minority of the ducts are cuffed and infiltrated by inflammatory cells and show only mild reactive changes such as increased nuclear:cytoplasmic ratio of the epithelial cells | 1 |
| Most or all of the ducts infiltrated by inflammatory cells. More than an occasional duct shows degenerative changes such as nuclear pleomorphism, disordered polarity and cytoplasmic vacuolization of the epithelium | 2 | |
| As above for 2, with most or all of the ducts showing degenerative changes or focal lumenal disruption | 3 | |
| Venous Endothelial Inflammation(V) |
lymphocytic infiltration involving some, but not a majority of the portal and/or hepatic venules | 1 |
| Subendothelial infiltration involving most or all of the portal and/or hepatic venules | 2 | |
| As above for 2, with moderate or severe perivenular inflammation that extends into the perivenular parenchyma and is associated with perivenular hepatocyte necrosis | 3 |
Total RAI Score = _/9
執筆日：2007/8/30
執筆者：神戸大学病院病理部病理診断科 伊藤 智雄
