Wotherspoon grading system of gastric MALT lymphoma
Wotherspoon Grade 0: Normal : Scattered plasma cells: no lymphoid follicles
Wotherspoon Grade 1: Chronic active gastritis: Small clusters of lymphoid cell in lamina propria: no lymphoid follicles or lymphoepithelial lesion
Wotherspoon Grade 2: Chronic active gastritis with florid lymphoid follicle formation: Prominent lymphoid follicles
Wotherspoon Grade 3: Suspicious lymphoid infiltrate, probably reactive: Lymphoid follicles surrounded by small lymphocyte that infiltrate diffusely in lamina propria and occasionaly into epithelium.
Wotherspoon Grade 4: Suspicious lymphoid infiltrate, probably lymphoma: Lymphoid follicles surrouded by CCL cells that infiltrate diffusely in lamina propria and into epithelium in small groups.
Wotherspoon Grade 5: Low-grade B-cell MALT lymphoma: Dense infiltrate of CCL cells in lamina propria; prominent LEL.
Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, Isaacson PG. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993 Sep 4;342(8871):575-7.
執筆者：神戸大学病院病理部病理診断科 伊藤 智雄 email@example.com