Wotherspoon grading system of gastric MALT lymphoma

Wotherspoon Grade 0: Normal : Scattered plasma cells: no lymphoid follicles

Wotherspoon Grade 1: Chronic active gastritis: Small clusters of lymphoid cell in lamina propria: no lymphoid follicles or lymphoepithelial lesion

Wotherspoon Grade 2: Chronic active gastritis with florid lymphoid follicle formation: Prominent lymphoid follicles

Wotherspoon Grade 3: Suspicious lymphoid infiltrate, probably reactive: Lymphoid follicles surrounded by small lymphocyte that infiltrate diffusely in lamina propria and occasionaly into epithelium.

Wotherspoon Grade 4: Suspicious lymphoid infiltrate, probably lymphoma: Lymphoid follicles surrouded by CCL cells that infiltrate diffusely in lamina propria and into epithelium in small groups.

Wotherspoon Grade 5: Low-grade B-cell MALT lymphoma: Dense infiltrate of CCL cells in lamina propria; prominent LEL.

Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, Isaacson PG. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori.　Lancet. 1993 Sep 4;342(8871):575-7.

執筆日：2006.7.20

執筆者：神戸大学病院病理部病理診断科　伊藤　智雄　　tomitoh@med.kobe-u.ac.jp